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Another study concluded that treatment with licorice and spironolactone reduced the activity of the renin-angiotensin system but did not affect the blood pressure in the treatment group [68]. reported that chamomile significantly decreased hemoglobin A1c (HbA1c), the insulin levels, total cholesterol, TG, and LDL-C [41]. Therefore, we conducted a meta-analysis to . Plausible role of Aloe vera in adipose tissue, liver, and muscle. However, the level of DHEA and total testosterone did not decrease substantially [54]. The effect of cinnamon extract on insulin resistance parameters in polycystic ovary syndrome: a pilot study. Pharmacognosy Res. The FASEB Journal. Mokhtari M, Ebrahimpoor MR, Harfsheno S. The effects of alcoholic extract of Marrubum vulgare on hormonal parameters in female rat model of polycystic ovarian syndrome. Tomatis V, Wassell S, Venables M, Walker C, Ray S, Siervo M, Griffin J, Bluck L. Effects of Green Tea and Coffee Polyphenols on Cardiometabolic Function in Women with Polycystic Ovary Syndrome. Cinnamomum is an herbaceous plant belonging to the Lauraceae family. 2007 Mar;131(1):617.10.1016/j.ejogrb.2006.10.013Search in Google Scholar Preliminary evidence that cinnamon improves menstrual cyclicity in women with polycystic ovary syndrome: a randomized controlled trial. We excluded studies unrelated to the PCOS and medical herbs. Dou L, Zheng Y, Li L, Gui X, Chen Y, Yu M, et al. CC is a non-steroidal selective estrogen receptor modulator, and although it has efficient stimulation on ovulation, but the pregnancy rate is not satisfactory [14]. PubMed, 54 Grant P. Spearmint herbal tea has significant anti-androgen effects in polycystic ovarian syndrome. 2018 Jun;500(3):797803.10.1016/j.bbrc.2018.04.162Search in Google Scholar Menta oil reduced body weight, testosterone concentration, ovarian cysts, and atretic follicles in PCOS rats. One study by Mehmet Akdogan et al. Managing polycystic ovary syndrome in primary care. Another study on premenopausal women with a similar methodology reported 46% reduction in cyst size and 71% of women reported the return of regular menstrual cycle after completion of the treatment [36]. Pharmaceutics. PubMed Central, 3 Mohseni Kouchesfahani H, Nabyooni M, Adham H. Investigating the therapeutic effect of eee venom on polycystic ovarian syndrome in rats. PubMed Balasubramanian A, Pachiappan S, Mohan S, Adhikesavan H, Karuppasamy I, Ramalingam K. Heliyon. 15 Biguanides also have some side effects on the human body such as gastrointestinal problems (nausea, diarrhea and abdominal pain) most commonly, and lactic acidosis . 2010 Feb;24(2):1868.10.1002/ptr.2900Search in Google Scholar, 55 Sadeghi Ataabadi M, Alaee S, Bagheri MJ, Bahmanpoor S. 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PCOS is a disorder characterized by abnormal gonadotropin secretion including Luteinizing hormone (LH) and Follicle-stimulating hormone (FSH), and increased secretion of ovarian steroids that may be associated with insulin resistance [4]. Vitex and lactone in Potentilla extract bind to the Dopamine receptor D2 (D2 R) of dopamine in the hypothalamus and glandular pituitary, thereby inhibiting prolactin secretion and reducing fibrocystic mastopathy [61, 64]. PubMed Conflict of interest: Authors state no conflict of interest, 1 Howe E. Polycystic ovarian syndrome. This study was a double blind randomized controlled trial (72 subjects) with pre-diabetes symptoms in 3 groups consumed capsules twice a day: Aloe vera 300 mg (AL300), 500 mg (AL500) and placebo (PL). Body weight (P = 0.02), body fat mass (p = 0.03) and insulin resistance were significantly lower in the intervention group. Phytother Res. Kerempour et al. 2009 Jul;124(3):47580. 2018 Oct;16(1):99.10.1186/s12958-018-0418-ySearch in Google Scholar 2019 Jun;9(6):215.10.3390/biom9060215Search in Google Scholar, 57 Sadrefozalayi S, Farokhi F. Effect of the aqueous extract of Foeniculum vulgare (fennel) on the kidney in experimental PCOS female rats. Polycystic ovary syndrome (PCOS) is an endocrine disorder related to elevated androgens (male hormones) in females in reproductive age. Ashkar F, Rezaei S, Salahshoornezhad S, Vahid F, Gholamalizadeh M, Dahka SM, Doaei S. Biomol Concepts. 2022 Sep 26;9(1):15-22. doi: 10.1002/osp4.639. We excluded studies unrelated to the PCOS and medical herbs. Mechanistic and therapeutic insight into the effects of cinnamon in polycystic ovary syndrome: a systematic review. PubMed Central, 37 Kayedpoor P, Mohamadi S, Karimzadeh-Bardei L, Nabiuni M. 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Silymarin influences glucose 6-phosphatase and inhibits gluconeogenesis, reduces blood glucose level, and thereby decreases the symptoms of the PCOS. ER stress attenuation by Aloe-derived polysaccharides in the protection of pancreatic -cells from free fatty acid-induced lipotoxicity. The association between obesity with serum levels of liver enzymes, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma-glutamyl transferase in adult women. Yang LL, Liang YC, Chang CW, Lee WS, Kuo CT, Wang CC, et al. 2015 Jan;145:21325.10.1016/j.jsbmb.2014.06.003Search in Google Scholar J Educ Health Promot. Animal Communication: When Im Calling You, Will You Answer Too? But, some plant remedies, herbs, and supplements such as aloe vera and. Hydroalcoholic extract of Heracleum persicum contain furocoumarins such as sphondin. J Nutr Sci. Deswal R, Yadav A, Dang AS. Another study reported that Heracleum persicum reduced LH, estradiol, and testosterone, while increased FSH in PCOS rats [51]. The effect of metformin and cinnamon on serum anti-mullerian hormone in women having PCOS: A Double-blind, randomized, controlled trial. 2018 Sep;7(3):26470. Insulin resistance improvement by cinnamon powder in polycystic ovary syndrome: A randomized double-blind placebo controlled clinical trial. At the end of the study, it was concluded that there was no significant change in BMI, weight, waist-hip ratio, and skin folds between the intervention and placebo groups. MeSH It helps to eliminate free radicals in the body and prevents peroxidation of lipids by increasing cellular glutathione [37, 38]. 2017 Oct;296(4):66177.10.1007/s00404-017-4480-zSearch in Google Scholar 2015 Apr;29(1_ supplement):LB271.10.1096/fasebj.29.1_supplement.lb271Search in Google Scholar, 32 Ghafurniyan H, Azarnia M, Nabiuni M, Karimzadeh L. 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Samaneh Mirzaei Dahka, Saeid Doaei* The Role of medicinal herbs in J Ethnopharmacol. This study reported that herbal medicines may have beneficial effects on PCOS. There was no change in fasting glucose, insulin sensitivity, and hormonal concentrations between the two groups [35]. Int J Morphol. The ginger and cinnamon supplementation increase catalase, glutathione peroxidase, and superoxide dismutase levels [27]. These include ginseng, magnesium, cinnamon, aloe vera, fenugreek, and others. Before Medical herbs may be an important role in PCOS treatment. Foeniculum vulgare (fennel) is used in traditional medicine to treat hormonal and metabolic disorders in women with PCOS. A significant reduction was seen in ovarian cysts after 2 months. Ainehchi N, Khaki A, Farshbaf-Khalili A, Hammadeh M, Ouladsahebmadarek E. The Effectiveness of Herbal Mixture Supplements with and without Clomiphene Citrate in Comparison to Clomiphene Citrate on Serum Antioxidants and Glycemic Biomarkers in Women with Polycystic Ovary Syndrome Willing to be Pregnant: A Randomized Clinical Trial. 2018 Nov;189:30814.10.1016/j.talanta.2018.07.012Search in Google Scholar, 62 Vickers NJ. Lua AC, How CH, King TF. ( 3) In general, the amount of cinnamon to take daily starts at 1/2 teaspoon. Cinnamon supplementation improved significant reduction in fasting glucose and insulin resistance. A review of 9 studies concluded that aloe vera really can lower blood sugar levels and promote better glycemic control. Chamomile tea significantly decreased HbA1C and serum insulin levels (p < 0.001), homeostatic no significant changes were reported in serum HDL. 2015;2015.10.1155/2015/659041Search in Google Scholar Aloe vera (AV), which . Natural substances such as Aloe vera, cinnamon, green tea, fenugreek, and silymarin can be used as a new supportive care for PCOS. 2013;12(2):47581. 2018 Mar;34(2):/j/hmbci.2018.34.issue-2/hmbci-2017-0067/hmbci-2017-0067.xml. Comparison of the effect between pioglitazone and metformin in treating patients with PCOS:a meta-analysis. Evidence-Based Complementary and Alternative Medicine. Fasting insulin, LDL-C, and insulin resistance were reduced after 12 weeks in intervention group compared with control group. Further clinical trials are warranted to confirm their benefits and safety. 2012 Apr;4(2):10915. PubMed, 40 Liu P, Cui L, Liu B, Liu W, Hayashi T, Mizuno K, et al.
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Improvement of glucose and lipid profile status with Aloe vera in pre Hassanzadeh Bashtian M, Emami SA, Mousavifar N, Esmaily HA, Mahmoudi M, Mohammad Poor AH. The Role of medicinal herbs in treatment of insulin resistance in patients with Polycystic Ovary Syndrome: A literature review. Chromium. Int J Endocrinol Metab 2011;9:33010.5812/kowsar.1726913X.1822Search in Google Scholar, 46 Heidary M, Yazdanpanahi Z, Dabbaghmanesh MH, Parsanezhad ME, Emamghoreishi M, Akbarzadeh M. Effect of chamomile capsule on lipid-and hormonal-related parameters among women of reproductive age with polycystic ovary syndrome.