PDAC is a highly aggressive cancer, and chemotherapy remains the cornerstone of advanced disease therapy. Our mission is to be your digital partner for Sustainability and Efficiency.https://www.se.com, COMMEO is synonymous with cutting-edge technology within a market place of the future. The necessary shielding for the motor connection can also be achieved with Han1A plastic connectors. Second-line chemotherapy was administered to 91 (73.4%) patients in the FOLFIRINOX group and 117 (70.9%) patients in the FOLFOXIRI group (P = 0.643). Certificates - Corporate Social Responsibility, Hand Crimp and Semi Automatic high-quality crimping tools, Rotatable vibration feeder and actuator in basic unit, Infinitely variable adjustment parameters, Air servicing unit with water separator and pressure reducer. Prior to shipment, all products undergo comprehensive mechanical testing and electronic performance verification according to widely recognized industry standards and customer specifications. Inter-car jumper cable systems based on customer requirements. With their compact design they support miniaturization. Specifically developed for the next generation of telecom, medical and industrial applications. Integrating IIoT functionalities has become essential for train companies and transit authorities who want to improve the safety, reliability, and maintenance of their systems. Henricks LM, Lunenburg CATC, de Man FM, Meulendijks D, Frederix GWJ, Kienhuis E, Creemers GJ, Baars A, Dezentj VO, Imholz ALT, Jeurissen FJF, Portielje JEA, Jansen RLH, Hamberg P, Ten Tije AJ, Droogendijk HJ, Koopman M, Nieboer P, van de Poel MHW, Mandigers CMPW, Rosing H, Beijnen JH, Werkhoven EV, van Kuilenburg ABP, van Schaik RHN, Mathijssen RHJ, Swen JJ, Gelderblom H, Cats A, Guchelaar HJ, Schellens JHM. The number of cycles was significantly higher in the FOLFIRINOX group (11.0 vs 7.0 cycles; P = 0.027). Drag-and-drop interactive tool that allows engineers, buyers, sales people and other users to select and customize electrical connectors that are used in a variety of industrial settings. Governor Rauner, HARTING and Elgin Mayor Kaptain announced that HARTING will expand it's manufacturing facilities creating 50 new jobs within 24 months. FOLFOXIRI is feasible in L1 in patients with aPDAC but does not confer any therapeutic benefit as compared with FOLFIRINOX. INSERM CIC-1431, Clinical Investigation Center in Biotherapy, Besanon University Hospital, Besanon F-25030, France. Connector Standard. Due to their resistance to environmental impacts, the hoods and housings are suitable for both indoor and outdoor applications. The unmanaged Ethernet switches from the Ha-VIS eCon series now offer you further new models with RJ45 and fiber optic cable ports to enable the efficient setup and expansion of your Ethernet networks. Trains are a critical form of moving people and things from one point to another. is based on the traditional DIN 41612 and is a customer configurable connector, for industrial board-to-board application.. For our most frequently installed solutions, we have also created video instructions. An official website of the United States government. For HARTING, the D-Sub is more than just a bus connector. Prior to shipment, all products undergo comprehensive mechanical testing and electronic performance verification according to widely recognized industry standards and customer specifications. The har-modular from HARTING, https://www.tme.eu/en/katalog/?search. for connecting high current components in power generation facilities. FOLFOXIRI was associated with a higher incidence of grade 3 or 4 digestive adverse events compared to FOLFIRINOX. Youll get even more. Special inserts and contacts are available to match the particular techniques of wire termination. The portfolio ranges from simple assembly and disassembly tools, manual and semi-automatic hand tools to fully automated machines for an efficient processing of contacts and connectors. Inserts in the eShop: Han D (7 - 128 Contacts, 10A / 50 - 250V)Han DD (24 - 216 Contacts, 10A / 250V)Han A (3 - 32 Contacts, 10 - 16A / 250 - 400V)Han E / ES / ESS (6 - 48 Contacts, 16A / 500V)Han EE (6 - 92 Contacts, 16A / 500V)Crimp terminationHan EEE (40 - 64 Contacts, 16A / 500V)For Han B hoods/housingsHan HsB (6 - 12 Contacts, 35A / 690V)For higher currents, Inserts in the eShop: Outcomes in the overall population and propensity score-matched population according to first-line chemotherapy, n (%). The Han-Smart generation brings the intelligence into the connector. Before Usn Junior PLS, Rother ET, Maluf FC, Bugano DDG. Vienot A, Chevalier H, Turpin A, Borg C, Vernerey D contributed to data interpretation. - for the perfect fit to your application, Proven hoods and housings made of powder-coated die-cast Aluminium, with convenient Han-Easy Lock, Lightweight hoods and housings made of high-performance plastic for indoor / outdoor applications, Single-handed operation, made possible through inner seal and locking levers, High-density transmission with multiple connectors, Device and electrical cabinet construction, Powder-coated die-cast zinc hoods and housings provide for excellent corrosion protection, Locking levers made of high-quality stainless steel, Special cable glands for hoods: with strain relief, kink protection and anti-twist protection, Applications with demanding environmental requirements, Aluminium die-cast hoods and housings, with electrically conductive surfaces and inner seals, Convenient locking levers of the Han-Easy Lock series, Sensitive interfaces that require shielding against electrical, magnetic or electromagnetic interference, Inner seal and corrosion-resistant aluminium die-cast alloy, persistent even under harsh environmental conditions, Stainless steel screws for vibration- resistant locking levers, Applications in rail vehicles and stationary railway technology, High pressure environments, protection tight seals, Extremely resistant to chemicals and other aggressive environmental influences, since hood/housing, locking lever and cable gland are made of stainless steel, Washing and painting facilities in production lines, Durable protection for electrical connections, even when they are exposed to daily treatment with high-pressure or steam cleaners, Design and materials are suited for food industry applications, Especially heat-resistant connector hoods and housings: can withstand up to 200 C due to high-strength materials and anti-stick coating. Intelligent, Modular, and Adaptive Production. VideoCall an Expert NOW! These dose adjustments were also effective in the neoadjuvant setting for patients with locally advanced or borderline PDAC. Using the crimping technique, the conductor ends and the conductive termination area of the contacts are crimped in a way that a homogeneous, electrically conductive areas is are formed. sharing sensitive information, make sure youre on a federal Hazard ratios (HRs) and 95%CIs were estimated using the IPTW Cox proportional hazards model. The two cohorts displayed similar characteristics, except for primary tumor site (located in the pancreatic head in 43.1% in the FOLFIRINOX group vs 56.7% in the FOLFOXIRI group; P = 0.022), histological grade, stage at chemotherapy initiation (88.7% had metastatic stage in the FOLFIRINOX group vs 63.6% in the FOLFOXIRI group; P < 0.001), and pain (corresponding to the prescription of morphine). Francine Fein, Department of Gastroenterology, Besanon University Hospital, Besanon F-25030, France. This is the concept behind HARTINGs IIoT Solution Packages. These results suggest that further evaluation of FOLFOXIRI in future clinical trials is not warranted. Properties Overview. . Austin PC, Schuster T. The performance of different propensity score methods for estimating absolute effects of treatments on survival outcomes: A simulation study. You can find all global dealers and distributors of HARTING products here. These results are in line with those observed in our study. P < 0.05 were considered statistically significant, and all tests were two-sided. A study that evaluated the FOLFIRINOX regimen in pancreatic cancer, reported a significantly higher incidence of diarrhea among patients with UGT1A1 heterozygous type (UGT1A1 /*6 and UGT1A1 /*28) compared to those with UGT1A1 wild-type (/). Injection molding machines are the center of the manufacturing process for many companies and, due to the materials and processes used, one of the most complex machines on the floor. The FOLFIRINOX regimen is the first-line reference chemotherapy (L1) in advanced pancreatic ductal adenocarcinoma (PDAC). Hard metric connectors in 2 mm contact pitch based on IEC 61076-4-101 with press-in technology. The primary analysis was conducted using data from the total population, and compared characteristics and outcomes between the FOLFIRINOX and FOLFOXIRI groups. FOLFOXIRI, a triplet-chemotherapy regimen with a lower dose of irinotecan and no bolus of 5-FU, has already demonstrated its efficacy and good tolerance and is validated in metastatic colorectal cancer[11,20]. From scanning groceries at a check out, to monitoring shipping containers as they cross oceans, below is a brief overview of the different technologies involved to make these types of applications happen. Networks in modern production facilities are becoming increasingly complex. Burris HA, 3rd, Moore MJ, Andersen J, Green MR, Rothenberg ML, Modiano MR, Cripps MC, Portenoy RK, Storniolo AM, Tarassoff P, Nelson R, Dorr FA, Stephens CD, Von Hoff DD. The unmanaged Ethernet switches from the Ha-VIS eCon series now offer you further new models with RJ45 and fiber optic cable ports to enable the efficient setup and expansion of your Ethernet networks. Building a predictive maintenance system. The preLink cabling system is an all-purpose cabling solution for IT, building automation and industry. Ethernet backbones and data infrastructures (e.g. ZUKEN E3.series data from the ZUKEN Component Cloud for or quick and easy use of HARTING products in ZUKEN E.series (2019+). How do you like our redesigned product page? In order to facilitate the installation or assembly of large parts of our connectivity solutions, HARTING publishes appropriate instruction manuals. University Bourgogne Franche-Comt, INSERM, EFS BFC, UMR1098, Interactions Hte-Greffon-Tumeur/Ingnierie Cellulaire et Gnique, Besanon F-25000, France. Rouits E, Boisdron-Celle M, Dumont A, Gurin O, Morel A, Gamelin E. Relevance of different UGT1A1 polymorphisms in irinotecan-induced toxicity: a molecular and clinical study of 75 patients. In our study, the two regimens were compared for the first time in routine clinical practice, taking into account a large number of variables. Dihydropyrimidine dehydrogenase and uridine diphosphate glucurono-syltransferase (UGT) 1A1 are two key enzymes involved in the catabolic pathways of 5-FU and irinotecan, respectively. HARTING PushPull connectors are heavy duty electricalconnectors that provide compact outdoor rated solutions for a safe shock-and-vibration-resistant connection. Amstutz U, Froehlich TK, Largiadr CR. Pour le plaisir ou la comptition, plus de 40 sports part For many years, D-Sub PCB connectors have provided a proven interface for data, signal and power supply in industrial applications. The flexible and reliable supply for fast, linearly moving components of machines and systems is achieved through the use of energy chains. In support of our connectors and system components, HARTING offers a selection of special tools and machines that make fast terminations and easy assemblies possible. Please contact the HARTING Customer Service for any questions concerning pricing and product availability or lead times. Department of Medical Oncology, Lille University Hospital, Lille F-59000, France. A higher incidence of adverse events was observed with the FOLFIRINOX group, including grade 3 or 4 neutropenia (45.7%), febrile neutropenia (5.4%) and diarrhea (12.7%)[7]. in engineering and robotics. A propensity score approach was then applied to deal with potential heterogeneity in baseline characteristics between the two administered regimens in L1. Dose reductions of single or multiple agents differ among studies compared to the standard schedule[24]. The site is secure. No: 21 04 316 2301 With conductors, for front mounting 50 cm. Hematopoietic growth factors were systematically used after each chemotherapy cycle in at least 80% of cases in the FOLFIRINOX group and for all patients enrolled in the FOLFOXIRI group. As observed for the overall population, characteristics were similar, except for histological grade, lymph node metastases, pain, and albumin level (39 g/L in the FOLFIRINOX group vs 34.6 g/L in the FOLFOXIRI group, P < 0.001). Infusion of 5-FU is preferred for the treatment of colorectal cancer over bolus 5-FU. World's first M8 D-code connector for 100 Mbit/s Fast Ethernet from the cloud to any sensor. Advanced or recurrent PDAC remains a challenging, non-curable disease, for which therapeutic options are still limited and mainly rely on supportive care and systemic chemotherapy to improve patient OS and health-related quality of life (HRQoL)[5]. Schneiders purpose is to empower all to make the most of our energy and resources, bridging progress and sustainability for all. Institutional review board statement: This project was approved by the National French Commission for bioinformatics data and patient liberty (CNIL; No. A guide to modularity in production technology, System concepts for the most important trends in the railway industry, Future outlook for DC connectivity in the industrial environment, Customised industrial connectors with the Han Configurator, Safe connections for modular battery storage systems, Simplifying electrical cabinet construction, free introduction to the Han Configurator, Many hood and housing options, sizes, designs, cable outlets, etc. This poor prognosis is mainly due to late diagnosis, with only 20% of patients with PDAC eligible for surgery. With the Han-Modular Flexbox, HARTING offers a novel interface in the modular plastic housing system. Please refer to product description. Kaplan-Meier curves of overall survival and progression-free survival for the FOLFIRINOX and FOLFOXIRI groups in the overall population and the propensity scorematched population. Plug-in cable assemblies simplify installation and reduce maintenance costs. In conclusion, FOLFOXIRI is feasible in L1 in patients with aPDAC, but does not appear to confer any therapeutic benefit as compared with the FOLFIRINOX regimen. OS rates at 12, 18, and 24 mo were 49.6%, 36.4%, and 28.3%, respectively, in the FOLFIRINOX group as compared with 45.1%, 30.9%, and 21.2%, respectively, in the FOLFOXIRI group.