Meguiar's M27 Pro Hybrid Ceramic Sealant, 16 oz. (E) Box-and-whisker plots of pole-to-pole distances as in (D) measured in 50 cells (two independent experiments). (D) Semi-quantitative LC-MS/MS results using fractional intensity-based absolute quantification (iBAQ) scores for the indicated dynein complex component proteins. The .gov means its official. p Values were calculated using the Mann-Whitney U test. Add To Cart. 2012 Mar 18;484(7392):125-9. doi: 10.1038/nature10936. Trims are protected so well that the like new appearance lasts for weeks, not days. Car plastic exterior trim is one area that's easy to overlook, but with one of these, you will have a great looking car guaranteed. Cerakote Cerakote Ceramic Trim Coat Kit Best overall plastic restorer Cerakote makes big promises. (E) Extracts from C3H10T1/2 and Shh-Light 2 cells were used, as well as (F) purified bovine dynein 1 as indicated. Also, can be used with foam or microfiber pads delivering more flexibility by increasing cleaning performance as needed. Exterior Trim Detailer G-13415 ~ Review - Car Care Forums: Meguiar's Online Bar, 4 m. For the best experience on our site, be sure to turn on Javascript in your browser. Economical sprayer yields a fine mist and is ideal for glass cleaner, mist and wipe products, and water based dressings. Comes in a reusable container to keep clay fresh, and comes with 200 grams of clay, Designed for 7" and 8" Soft Buff Rotary pads, Allows quick and easy pad changes with hook and loop attachment system, Self-centering system guarantees pad balance, Fits all rotary polishers with 5/8" diameter shaft, Provides excellent balance and performance, Improved foam technology cuts through moderate surface defects with fewer swirls, 7" pad size reduces chatter resulting in smooth, easy buffing, Recessed backing for easy centering with reduced operating temperature, For use with Rotary Polisher and Meguiar's Soft Buff Rotary Backing Plate - WRBP or Meguiar's Soft Buff Rotary Soft Backing Plate - WRSBP, Improved foam technology eliminates minor surface defects while restoring a luxurious high gloss finish, Eliminates minor surface defects while restoring gloss, Designed for 7" and 8" Soft Buff rotary pads, Effectively contours to curves and body lines, Distributes pressure for smoother buffing; more forgiving, less swirls, Long lasting, one-piece molded construction, Fits all Rotary Polishers with 5/8" diameter shaft, 8" pad with 1.25" 4-ply twisted fibers for faster cutting, Effective removal of sanding marks and severe defects, Quick change hook and loop attachment system, 7" pad with 1" twisted wool fibers for faster cutting, Effective for removal of sanding marks and defects, Flat pad design expands cutting area to reduce buffing time, Meguiar's Soft Buff Rotary Backing Plate - WRBP or Meguiar's Soft Buff Rotary Soft Backing Plate - WRSBP, Removes severe to moderate surface defects, Optimized for use with Meguiar's DA Microfiber Correction Compound - D300, For use with dual action polisher like Meguiar's MT300 Dual Action Polisher and Meguiar's DBP6 6" DA Backing Plate, For use with dual action polisher like Meguiar's MT300 Dual Action Polisher and Meguiar's DBP5 5" DA Backing Plate, Engineered formula to remove compounding DA haze, Provides complete paint refinement for a defect-free finish, Perfect intermediate step between Meguiar's DA Microfiber Compound - D300 and Meguiar's DA Microfiber Finishing Wax - D301, for the ultimate finish with exceptional shine, Doesn't sling or dust, and is easy on, easy off, Ideal results are achieved when used with Meguiar's MT300 Dual Action Polisher and Meguiar's DA Microfiber Finishing Disc DMF3, DMF5, DMF6, Wash & Wax all exterior vehicle surfaces without rinsing, Quick and easy wipe off, with biodegradable detergentsSecondary label (#VSLD115) available for placement on application container, Effective and easy cleaning on wheels and tires, Quickly removes brake dust, road grime, light grease and dirt, Fast cutting compound with advanced technology, Quick removal of 1200 grit and finer sanding marks for easier polishing, Removes deep scratches, acid rain, and severe swirls/holograms, Works great on fresh and cured paints, and is safe and effective on all glossy paint finishes including clear coats, Formulated for use with a Rotary Buffer, and is body shop safe, Larger 1 gallon bottle is more cost effective for body shops and professional detailers, 3 button selector dial dispenses up to 6 different concentrates, Metered, accurate dilutions minimize waste and reduce labor costs by eliminating manual mixing, Locking buttons for auto fill of large containers, Includes tubes, metering tips, and color coded label kit, Capable of metering high viscosity products, Fast fill, 4 GPM fill for car wash product, ALL-IN-ONE KIT: Safe, simple, user-friendly kit includes the products you need to remove defects and add glossy protection to your paint finish without creating swirls, IDEAL USE: Ideally used with Meguiar's MT300 Dual Action Polisher, but can be used with any DA Polisher, MICROFIBER PADS: Includes DA Microfiber Cutting Discs and DA Microfiber Finishing Discs to deliver exceptional polishing and finishing results, LESS MESS: DA Microfiber Correction Compound and DA Microfiber Finishing Wax are formulated for minimal dusting and no slinging, which means less mess and cleanup, MEGUIARS MICROFIBER: Kit includes 2 5" DA Microfiber Cutting Discs, 2 5" DA Microfiber Finishing Discs, 5" DA Backing Plate, 16 oz D300 DA Microfiber Correction Compound, 16 oz D301 DA Microfiber Finishing Wax and Meguiars Mirror Glaze Shop Apron, Engineered foam interface for optimal cutting efficiency, and controlled conformability, Optimized for use with DA Microfiber Finishing Wax-D301, Hook and loop system on the DA Microfiber Disc sticks firmly to, and ideally mates up with Meguiar's DBP6 - 6" DA Soft Buff Backing Plate, Aggressive enough to remove moderate defects but gentle enough that it won't create swirls, Optimized for use with DA Correction Compound-D300, Specially formulated to optimize and refine the surface after applying Meguiar's DA Microfiber Cutting Compound - D300, Rich blend of polymers, silicones, and carnauba for high gloss protection, No sling and low dusting performance with one-pass wipe off make it easy with less clean up, Lightly cleans the paint and leaves behind a durable, high gloss protection, Ideal results are achieved when used with Meguiar's MT300 Dual Action Polisher and Meguiar's DA Microfiber Finishing Disc - DMF3, DMF5, DMF6, Super-Micro Abrasive Technology (SMAT) quickly removes moderate defects, Formulated to remove light to moderate flaws while creating a high gloss, No sling and low dusting formula for minimal prep and clean up, Rich concentrated formula delivers lower cost per car, A less aggressive alternative to a Rotary Buffer for removing moderate defects in OEM paint, Ideal results are achieved when used with Meguiar's MT300 Dual Action Polisher and Meguiar's DA Microfiber Cutting Disc -DMC3, DMC5, DMC6 or Meguiar's DA Microfiber Xtra Cutting Disc - DMX5, DMX6, Colorless with a pleasant citrus fragrance, Clear cap for quick product identification, Safe and simple, user-friendly system will remove moderate defects without producing swirls and restore your vehicle's smooth gloss in just two easy steps, Meguiar's DA Microfiber Cutting Disc and Meguiar's DA Microfiber Finishing Disc together provide exceptional polishing power and finishes perfectly delivering amazing results quickly. Firestone AJ, Weinger JS, Maldonado M, Barlan K, Langston LD, O'Donnell M, Gelfand VI, Kapoor TM, Chen JK. official website and that any information you provide is encrypted Tagay Y, Kheirabadi S, Ataie Z, Singh RK, Prince O, Nguyen A, Zhovmer AS, Ma X, Sheikhi A, Tsygankov D, Tabdanov ED. Copyright 2018 Elsevier Ltd. All rights reserved. government site. Gold Class Trim Detailer Meguiar's Australia https://www.meguiars.com/sites/default/files/pdf/G108%20SDS.pdf Right now, it's $8 off, so grab it while you can. For the best experience on our site, be sure to turn on Javascript in your browser. Epub 2023 Apr 5. Clearance. As such, dynarrestin is a valuable tool for probing cytoplasmic dynein-dependent cellular processes and a promising compound for medicinal chemistry programs aimed at development of anti-cancer drugs. Meguiar's Detailer products are the perfect solution for anyone running a garage, washing and detailing several cars a week, and commercial car washes. Flagship Premium. and transmitted securely. FOIA High quality, budget-friendly products from the brand that is synonymous with car care . ciliary transport; ciliobrevin; dynein; glioblastoma; hedgehog; intraflagellar transport; phenotypic screening; stem cell-based phenotypic screening; vismodegib. But the trim restorer product itself works well and it's super easy to apply to parts of the car some of the other picks on this list don't do well with. Mol Biol Cell. MeguiarsDirect.com is an authorized independent online retail store owned and operated by Shine Distributing. Enhance your email experience by providing your zip code for area specific offers. Epub 2018 Dec 17. Loss of dynein-2 intermediate chain Wdr34 results in defects in retrograde ciliary protein trafficking and Hedgehog signaling in the mouse. Clipboard, Search History, and several other advanced features are temporarily unavailable. We strive to empower all people with the ability to create awe-inspiring results they can be proud of because we believe every . Meguiar's Hybrid Ceramic Trim Restorer, 16 oz. Infante P, Alfonsi R, Ingallina C, Quaglio D, Ghirga F, D'Acquarica I, Bernardi F, Di Magno L, Canettieri G, Screpanti I, Gulino A, Botta B, Mori M, Di Marcotullio L. Cell Death Dis. Meguiar's Mirror Glaze Professional Medium-Cut Cleaner, M0116, 16 oz. PDF Patient information before data transfer to the state cancer register NRW order Accessibility 2016 Sep 22;7(9):e2376. I use it on any trim and on the wheel wells for a quick and easy shine. 2023 May 15;34(6):ar63. Meguiar's Gold Class Trim Detailer 298ml - Repco Australia Meguiar's Gold Class 64 Ounce Car Wash Shampoo And Conditioner - G7164. Again, it's pricey, but you get what you pay for here. $13.99. Foremost, it's nice the folks at the company include an applicator. (IL) Dot plots of particle (I) run lengths and (J) velocities in 500 s observation (50 s/cell, 10 cells/condition). (A) IFT88-GFP (green) and Arl13b-mCherry (red) in primary cilia, Figure 7.. Dynarrestin Inhibits Tumor Cell Proliferation, Figure 7.. Dynarrestin Inhibits Tumor Cell Proliferation Independently of Smoothened Binding, MeSH Dynarrestin acts reversibly to inhibit cytoplasmic dynein 1-dependent microtubule binding and motility in vitro without affecting ATP hydrolysis. Meguiar's Supreme Shine Wheel Brush - Medium. Meguiar's New Boat Owner's Essentials Box. It all started with Gran Turismo. (C) Immunostaining for acTubulin of cells induced to form primary cilia under the indicated conditions. It's the little things that matter when it comes to making a car look clean and well maintained. (A) Maximal projection of 50 s movies illustrating movements of rhodamine-MTs driven by purified bovine dynein in samples incubated for 30 min in 25 M L557 and dynarrestin. Meguiar's G9719 Carpet & Upholstery Cleaner - 19 oz. Instead, it's a coating to restore. Marine/RV. 10 Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA. Thankfully, there is a fine selection of plastic restorer products that can make it look new again. . (H) Images showing the maximal projection of particle movements in 50 s. Scale bar, 5 m. EMBO Rep. 2022 Nov 7;23(11):e55251. Federal government websites often end in .gov or .mil. Figure 3.. Dynarrestin Inhibits Dynein-1-Dependent Microtubule Gliding. Taros Chemicals | 3,559 followers on LinkedIn. Meguiar's M210 Mirror Glaze Ultra Pro Finishing Polish, 32 oz. Meguiar's Hybrid Ceramic Detailer - 26 oz. First Impressions: Its packaged in a aerosol with three settings on the spray nozzle, this is VERY useful. See also Figure S4. Professional Products | Meguiar's However, these little car trim restorer wipes pack a big punch. Yellow lines highlight the moving particles. (A) Smoothened and acetylated tubulin (acTubulin) in primary cilia. Scale bar, 5 m. Meguiar's Hybrid Ceramic Trim Restorer, Car Trim Plastic Restorer - 16 Meguiar's Direct PRO-STRENGTH: Highly effective pro-strength iron remover engineered for both wheels & paint, COLOR CHANGING FORMULA: No compromise formula rapidly removes iron and changes colors, GENTLE: pH neutral formula is safe on all wheels & painted brake components, CLINGING ACTION: Gel formula clings to wheels to remove road grime, grease & iron, SAFE AND EFFECTIVE: Safely and effectively removes iron particles from body panels too. Cell Rep. 2023 Jan 31;42(1):111969. doi: 10.1016/j.celrep.2022.111969. (F) Dynein ATPase activity of purified porcine brain dynein in the presence of MTs. For the best experience please upgrade or visit the site on another browser. 2020 Mar 30;133(6):jcs240614. Future Med Chem. Sign up for exclusive email offers & news. (EG) Chemical structure of dynarrestin analogs (E). Meguiar's Mirror Glaze Professional Machine Glaze, M0316, 16 oz. I have used it one 3 cars so far and it looks great on each. RTU, Meguiar's D107 Citrus Power Cleaner Plus, 32 oz. 2023 Apr 5:2023.04.04.535605. doi: 10.1101/2023.04.04.535605. Meguiar's Supreme Shine Microfiber Towel (3 pack). Aberrant hedgehog (Hh) signaling contributes to the pathogenesis of multiple cancers. This page was generated at 1 minute ago. MULTIPLE USES: Versatile and dilutable formula works as a spray sealant, boosted detailer & clay lube. Meguiar's Gold Class Products | O'Reilly Auto Parts JavaScript seems to be disabled in your browser. 2023 CNET, a Red Ventures company. RTU, Meguiar's D170 Hyper Dressing, 32 oz. Meguiar's Marine/RV One-Step Cleaner Wax, 16 oz. However, at $12, Meguiar's Ultimate Black is an exterior trim restorer that's worth its price. (C) Chemical structure of dynarrestin. Can be used with a Dual Action Polisher, like Meguiar's MT300 Dual Action Polisher, but ideal for use with forced rotation polisher or pneumatic, Meguiar's DA Microfiber Correction Compound and Meguiar's DA Microfiber Finishing Wax formulated to produce minimal dusting and no slinging for less mess and clean up, Includes free Meguiar's Black Detailing Apron, Uniform grit particles leave a smooth, even sanding pattern that buffs out in seconds, Eliminates the risk of deep, uneven sanding scratches, Economical to use - works faster and lasts longer, Won't load up as quickly as conventional sanding products, Safe for use on all paint finishes and comes in waterproof, half sheets (5.5" X 9"), Apply Meguiar's secondary labels for quick product identification, Fast paint defect removal, incredible high shine, and wax protection in one easy step, True scratch and defect removal coupled with durable, long-lasting protection, Easy on, easy off and can be applied by hand, dual action polisher, or rotary, Ideal for high volume reconditioning facilities, detail shops, and dealerships to obtain brilliant results fast, Safe and effective on clear coat and single stage paint, Formulated for use by Hand, DA Polisher and Rotary Buffer, Easy to use mist on, wipe off for deep shine and durable protection, Can be applied in direct sunlight, and dries clear on plastic trim, Hydrophobic Polymer Technology allows moisture to bead and roll off the waxed paint, DETAILER SPRAY: Simply spray on and wipe off for incredible depth, shine and gloss, SHOWROOM SHINE: Creates a showroom shine while enhancing protection, CLAY LUBRICANT: Excellent for use as a clay lubricant when diluted 1:1 with C2000 or C2100. RTU, Meguiar's D155 Last Touch Spray Detailer, 32 oz. Versatile product can be used by Hand, Dual Action Polisher, or Rotary. We strive to empower all people with the ability to create awe-inspiring results they can be proud of because we believe every ride matters! I dig Carfidant's Trim & Plastic Restorer. Effects of the indicated compounds in assays of (F) Hh-dependent osteogenesis of C3H10T1/2 cells and (G) luciferase activity using Shh-LIGHT2 cells. This product is already in your wish list. These products restore the faded plastic to a dark, deep black color reminiscent of how it looked when it rolled off the production line. Box-and-whisker, which indicate minimum to maximum, plots for label-free quantitative (LFQ) LC-MS/MS results for (B) DYNC1I2 as well as (C) DYNC1LI1, which are both part of the cytoplasmic type-1 dynein protein complex. M10 Mirror Glaze Clear Plastic Polish, 8 oz, Meguiar's Mirror Glaze Professional Vinyl & Rubber Cleaner/Conditioner, M4001, 1 Gallon. Find all of your favorite Meguiar's products, plus tips and advice on how to get the results you've always dreamed of. Electronic address: schroer@jhu.edu. Many of its historical buildings have . Meguiar's Mirror Glaze Professional Unigrit Sanding Block - 2,000 Grit, K2000, Sanding Block, Meguiar's Mirror Glaze Professional Unigrit Sanding Block - 1,500 Grit, K1500, Sanding Block, Meguiar's Mirror Glaze Professional Unigrit Sanding Block - 1,000 Grit, K1000, Sanding Block, Meguiar's Mirror Glaze Unigrit Finishing Paper, S3025, 3000 Grit, 25 SHEETS, Meguiar's Mirror Glaze Unigrit Finishing Paper, S2525, 2500 Grit, 25 SHEETS, Meguiar's Mirror Glaze Unigrit Finishing Paper, S1525, 1500 Grit, 25 SHEETS, Meguiar's Mirror Glaze Unigrit Finishing Paper, S1225, 1200 Grit, 25 SHEETS, Meguiar's Mirror Glaze Unigrit Finishing Paper, S1025, 1000 Grit, 25 SHEETS, Meguiar's E7200 Mirror Glaze High-Tech Backing Pad, Meguiar's Dispenser Bottle with Sprayer, M9911, 32 oz., empty. Keywords: Meguiar's Marine/RV Hard Water Spot Remover, 16 oz. See also Figure S3 and Table S1. Trim Detailer also helps remove unwanted contaminants and wax residue. Meguiar's Quik Interior Detailer Cleaner - 16 Oz Spray Bottle RTU, Meguiar's D143 Non-Acid Wheel & Tire Cleaner, 32 oz. Identification of Dynarrestin. (A) IFT88-GFP (green) and Arl13b-mCherry (red) in primary cilia of serum-starved IMCD3 cells after treatment with 1 % DMSO, 1.25 M dynarrestin for 1 hr, or 1 hr after dynarrestin washout. See also Figures S1 and S2. (D) Dot plots of IFT88-GFP particle velocities in 600 s observation (60 s/cilium, 10 cilia/condition). (E) Average gliding velocities by dynein-1 in various concentrations of dynarrestin (red) or L557 (blue) treatment, or by kinesin-1 (green) in dynarrestin treatment (mean SD, three experiments; n > 150 MTs). Flagship Premium. Apply Trim Detailer with an Applicator Pad for best results. Meguiar's Mirror Glaze Professional Show Car Glaze, M0716, 16 oz. sharing sensitive information, make sure youre on a federal (C and D) Schematics illustrating pole-to-pole distances (D) measured from the confocal images (D) and , the angle between the spindle axis (orange line) and the coverslip (C). Meguiar's Hot Rims Black Wheel Cleaner, 24 oz. The https:// ensures that you are connecting to the Disclaimer. If your exterior grey or black trim pieces don't look quite as dark or as rich as they used to, Hybrid Ceramic Trim Restorer will revitalize it, add a dark rich shine, and it will offer much-needed hybrid ceramic protection to defend against the sun and elements. Please enable it to take advantage of the complete set of features! EXTREME GLOSS: Creates deep, glossy finish without swirls or holograms, CLEANER POLISH: Designed to remove DA haze or Rotary swirls and leave a flawless finish, EASY TO USE: Easy wipe-off, virtually zero dusting or sling with Rotary or DA Polisher, FLAWLESS FINISH: Engineered for flawless finish after Meguiars M110 Ultra Pro Speed Compound even on dark & sensitive paints, QUICK & CONSISTENT: Fast, even cut with extremely high gloss finish, PRO AUTO BODY COMPOUND: Pro-grade compound for quick removal of 1,200 grit or finer sanding marks, VERSATILE USE: Incredible results with short & long-throw DA, or Rotary, EASY TO USE: Easy wipe-off, virtually zero dusting or sling with long work cycle, PRO RESULTS: For optimum show car results, follow with Meguiars M210 Mirror Glaze Ultra Pro Finishing Polish to refine paint to a deep, glossy finish, Concentrated formula is fast and effective for both interior and exterior cleaning across many surfaces, Advanced formula is solvent-free and low foaming for safe and effective cleaning, Safe on carpet, upholstery, leather, plastics, engines, wheel wells, painted wheels, tires and more, Ideal for use in hot or cold extractors, air-powered tools and via spray bottle, Available in both 1-gallon and 5-gallon containers, Citrus Blast scent & high lubricity cleaners are sure to make this a new favorite bucket wash among pros and enthusiasts, Specially formulated to clean all of your vehicles exterior surfaces using less time and water, Premium high-gloss carnauba wax protection offers noticeable pop and gloss, Unique formula allows foam to quickly break and saves precious water during rinse step. 11 . Careers. Meguiar's Marine/RV Fiberglass Restoration System. Ideal for use with Meguiar's M34 Mirror Glaze Final Inspection or D155 Last Touch Spray Detailer diluted 1:1 as lubricant to gently wipe away overspray, bug debris, fresh water spots, tree sap mist, road tar and other surface contaminants. store Meguiars most advanced one step that saves on time and money by presenting a great alternative. Bookshelf Like it says, this isn't a dressing, but a protective coating that restores the plastic trim. (BD) Effects on spindle orientation and pole-to-pole distance. Meguiar's Ultimate Black Plastic Restorer (Aerosol), 10 oz. Severely oxidized surfaces benefit from 2-3 applications as additional applications can improve darkness. $82.99. You are right about the gloss on the bumper, too much for my taste also. Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein. MeguiarsDirect.com is the Official site for Meguiar's, the trusted experts in surface care since 1901.
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